Carotenoid
group of the University of Western Brittany
(Université de Bretagne Occidentale / CNRS,
France)
Main
interests :
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Carotenoid
group of the University of Western Brittany |
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Main
interests :
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microbial production of carotenoids | ||
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new strategies for the synthesis of retinoids and carotenoids | ||
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| Current projects : | ||
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 Microbial
production of aryl carotenoids (isorenieratene and related xanthophylls) bacteria investigated (Brevibacterium linens, Streptomyces mediolani, Mycobacterium aurum) |
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New
strategies for syntheses of aryl carotenoids We have recently patented a biomimetic synthesis of ø,ø-carotene (isorenieratene). The new reaction permits to convert ß-ionone into its aromatic analogue which is further condensed with an easily available synthon, leading to the retinal analogue. A low-valent titanium coupling led to isorenieratene. |
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| Members : | |
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Zo
Andriamialisoa
Adrien Binet Dominique Cartier Laurent Dufossé Patrick Galaup Roger Labia Régis Le Guillou Stéphanie Savy Benoist Valla Alain Valla |
| References : |
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Biodiversity of the pigmented microflora isolated from the rind of French red-smear ripened soft cheeses. Dufossé L., Galaup P. Oral communication, 1st FEMS Congress of European Microbiologists, Ljubljana, Slovenia, June 29 – July 3, 2003. Regioselective one-pot synthesis of all E retinoic acid from a new enaminodiester synthon. Cartier, D.; Valla, A.; Labia, R. and Potier, P. Eur J. Org. Chem. 2003, in press. Two-carbones homologation of methyl ketones examplified for the synthesis of citral from 6-methyl-5-hepten-2-one. Valla, A.; Cartier, D.; Laurent, A.; Valla, B.; Labia, R. and Potier, P. Synth. Comm. 2003, 33, 1195-2003. Final step of carotenoid biosynthesis in Brevibacterium linens, a bacteria involved in the coloration of red-smear ripened soft cheeses. Savy S., Dufossé L. In : “ Functionalities of pigments in food ”, Empis J. (Ed), © Sociedade Portuguesa de Quimica Publ., ISBN 972-960-65-8-7, 293-297, 2002. A New Regioselective Synthesis of Acitretin (Soriatane ®, Neotigason ®). Andriamialisoa, Z.; Valla, A.; Cartier, D. and Labia, R. Helv. Chim. Acta, 2002, 85, 2926-2929. Coloration of red-smear ripened soft cheeses : pigmented microflora versus added colorants. Dufossé L. In : “ Functionalities of pigments in food ”, Empis J. (Ed), © Sociedade Portuguesa de Quimica Publ., ISBN 972-960-65-8-7, 341-345, 2002. New synthetic analogs of retinoids: synthesis of aromatic 9-methylene and 9-methylene-13-demethyl analogs of retinol, retinal and ethyl retinoate. Valla, A.; Prat, V.; Laurent; A.; Andriamialisoa, Z.; Cartier, D.; Giraud, M.; Labia, R. and Potier, P. Helv. Chim. Acta, 2001, 84, 3423-27. Synthesis of new ethyl 9-methylene-13E and 13Z retinoates via the Julia olefination reaction. Valla, A.; Laurent, A.; Prat, V.; Andriamialisoa, Z.; Cartier, D.; Giraud, M.; Labia, R. and Potier, P. Tetrahedron Lett. 2001, 42, 4795-97. Synthesis of 9-methylene analogs of retinol, retinal, retinotrile and retinoic acid. Valla, A.; Prat, V.; Laurent, A.; Andriamialisoa, Z.; Giraud, M.; Labia, R. and Potier, P. Eur. J. Org. Chem. 2001, 1731-34. Stereoselective synthesis of 9-methylene-13-demethyl analogs of natural retinoids. Valla, A.; Prat, V.; Laurent, A.; Andriamialisoa, Z.; Cartier, D.; Labia, R. and Potier, P. Synth. Comm. 2001, 31, 3219-23. Assessment of the coloring strength of Brevibacterium linens strains : spectrocolorimetry versus total carotenoid extraction / quantification. Dufossé L., Mabon P., Binet A. Journal of Dairy Science, 2001, 84(2), 354-360. Characterization of Brevibacterium linens pigmentation using spectrocolorimetry. Guyomarc’h F., Binet A., Dufossé L. International Journal of Food Microbiology, 2000, 57(3), 201-210. Production of carotenoids by Brevibacterium linens : variation among strains, kinetic aspects and HPLC profiles. Guyomarc’h F., Binet A., Dufossé L. Journal of Industrial Microbiology & Biotechnology, 2000, 24(1), 64-70. Coloration of red-smear ripened soft cheeses and related ones. Dufossé L. Oral communication, 4th International Symposium on Natural Colorants, San Diego, USA, April 2-5 2000. Synthesis of new 9 and 13-methylene isomers of retinal. Laurent, A.; Prat, V.; Valla, A.; Andriamialisoa, Z.; Giraud, M.; Labia, R. and Potier, P. Tetrahedron Lett. 2000,.41, 7221-24. Syntheses of New Cyclic Retinoids via Base Induced Self-Condensation of C-13, C-14 and C-15 Units. Valla, A.; Andriamialisoa, Z. and Labia, R. Tetrahedron Lett. 2000, 41, 3359-62.
Contact:
Laurent DUFOSSE, University of Western Brittany |
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Carotenoids from
food products